Background: We modified and reconstructed a high image quality portable non-mydriatic fundus camera and\ncompared it with the tabletop fundus camera to evaluate the efficacy of the new camera in detecting retinal diseases.\nMethods: We designed and built a novel portable handheld fundus camera with telemedicine system. The image\nquality of fundus cameras was compared to that of existing commercial tabletop cameras by taking photographs\nof 364 eyes from the 254 patients. In all 800 fundus images taken by two camera types, 400 images per camera,\nwere graded with the four image clarity classifications.\nResults: Using the portable fundus camera, 63% (252/400) images were graded as excellent overall quality, 20.5%\n(82/400) were good, 11.75% (47/400) were fair, and 4.75% (19/400) were inadequate. Using the tabletop fundus\ncamera, 70.75% (283/400) images were graded as excellent overall quality, 20.4% (51/400) were good, 13.25% (53/400)\nwere fair, and 3.25% (13/400) were inadequate. Common retinal diseases were easily identified from fundus\nimages obtained from the portable fundus camera.\nConclusion: The new type of non-mydriatic portable fundus camera was qualified to have professional quality of\nfundus images. The revolutionary screening camera provides a foundational platform which can potentially improve\nthe accessibility of retinal screening programmes.
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